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High-dose vitamin d relieves pain for many patients of breast cancer with estrogen-lowering drugs, a new study shows. Credit: Michael c. Purdyhigh-dose vitamin d relieves pain for many breast cancer patients estrogen-lowering drugs, according to a new study from Washington University School of medicine in St. Louis.Drugs, known as aromatase inhibitors, commonly referred to shrink breast tumors that are powered by the hormone estrogen and help prevent recurrence of cancer. It is less toxic than chemotherapy, but for many patients, the drug can cause serious musculoskeletal discomfort, including pain and stiffness in the hands, wrists, knees, hips, lower back, shoulders and legs.
"Approximately half of patients may experience these symptoms," says Antonella Rastelli l., MD, Assistant Professor of medicine and first author of the study, published online in the Journal for research on breast cancer and treatment. "We do not know exactly why pain occurs, but can be very debilitating — the point that patients decide to block the aromatase inhibitors."
This video is not supported by your browser at this time.Washington University physicians found that high doses of vitamin d helps to relieve pain in breast cancer patients estrogen-lowering drugs. Known as aromatase inhibitors, drugs to treat breast tumors being supplied by the hormone estrogen. It is less toxic than chemotherapy, but many patients experience severe musculoskeletal discomfort, including pain and stiffness in the hands, knees, hips, lower back, shoulders and legs. Credit: Clark BowenBecause drugs reduce recurrence of cancer, found a way to help patients remain on is important for long-term survival without relapse, according to Rastelli. Aromatase inhibitors are prescribed to post-menopausal women for at least five years and more frequently after the diagnosis of breast cancer. There is some evidence that patients have the experience of drug side effects are less likely to see the cancer returned, providing even more incentive to help these patients still.Rastelli was by Marie e. Taylor, MD, Assistant Professor of Radiation Oncology, who first noticed that patients with aromatase inhibitors that experienced this pain found some relief from high doses of vitamin d.
Both the Group recruited Rastelli 60 patients reported pain and distress associated with anastrozole, one of the three FDA-approved aromatase inhibitors. Patients examined also had low vitamin d levels. Half of the Group were randomized to receive the recommended daily intake of vitamin d (400 IU) plus a capsule unit-50,000 vitamin d once a week. The other half received the daily intake of 400 units of vitamin d plus weekly placebo. All subjects received 1,000 milligrams of calcium daily throughout the study.
Patients in the study reported no pain suffered through three different questionnaires. They were asked to quantify the intensity of pain, as well as the report how the pain changed the climate, influenced their work and in relationships and everyday activities. The results show that patients with high-dose vitamin d each week reported significantly less musculoskeletal pain and also were less likely to experience the pain that interfered with daily life.
"High-dose vitamin d seems to be really effective at reducing musculoskeletal pain caused by aromatase inhibitors," says Rastelli. "Patients the impression weekly vitamin d better because their pain and sometimes strays completely reduced. This makes the drug much more tolerable. Millions of women worldwide to aromatase inhibitor therapy, and can we have another ' tool ' to remain in this anymore. "
Anastrozole as used in this study, two other aromatase inhibitors approved by FDA, letrozole and exemestane, should also give rise to musculoskeletal pain. Taking into account the similar reactions, Rastelli says patients about these drugs may benefit from high doses of vitamin d.
Vitamin used in this study is of a type derived from a plant called Vitamin D2. Rastelli says that achieves the best results when given weekly, because this body metabolizes within seven to 10 days. Rastelli and her colleagues used high-dose Vitamin D3, which remains in the body longer.
"This was a very carefully conducted study, and the control of the standard makes the findings very impressive," says Matthew j. Ellis, MD, Ph.d., senior author of the study and Director of the breast cancer program at the Center, Alvin j. Siteman cancer at Barnes-Jewish Hospital and Washington University School of medicine in St. Louis. "We have to take up these findings further to determine the most effective and safe approach for additional vitamin d in our patients with breast cancer."
Since vitamin d helps the body absorb calcium, too much of it can cause high levels of calcium in the urine, which may increase the risk of kidney stones. Possible reactions to stress the importance of patient monitoring urine calcium levels taking high doses of vitamin d.
"It is important to monitor patients, but overall it seems to be very safe," says Rastelli. Because Vitamin D2 is removed from the body so quickly, it is very difficult to overdose. "
In addition to the relief of pain, the Group wanted to examine whether it could protect vitamin d in the loss of bone that is often regarded as aromatase inhibitors in patients. The researchers measured each patient bone density at the beginning of the study again after six months.
Perhaps because of its role in calcium absorption, high-dose vitamin d appear to contribute to the maintenance of bone density in the neck of the femur, at the top of the thighbone near hip hinge. Although the result did not reach statistical significance, Rastelli calls the promising and worth further study.
"Great to have something simple as vitamin d to help patients to alleviate some of this pain," says Rastelli. "It is not toxic — does not cause significant side effects. And if that is actually to protect against bone loss, which is even better. "
More info: Rastelli AL, Taylor, Gao F, Armamento Villareal-R, S-Jamalabadi Majidi, Napoli n., Ellis, MJ. Vitamin d and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial separated. Research on breast cancer and treatment. Online June 2011.
Provided by Washington University School of Medicine (news: web)
An international team of scientists led by researchers at the University of California, San Diego School of Medicine (UCSD), and the Scripps Translational Science Institute (STSI) in La Jolla, CA, has identified possible genetic variations that could affect the patient's recovery from an eating disorder such as anorexia or bulimia. Their findings, reported online in the Journal Neuropsychopharmcology, may provide new insights into developing effective interventions for more treatment-resistant patients with these disorders.
"This study highlights important ' or ' genetic variations SNPs within a person's DNA, associated with long-term, chronic eating disorders," said Walter h. Kaye, MD, Professor of Psychiatry and Director of the UCSD eating disorder treatment and research program, who was a senior writer with Ph.d., Nicholas j. Schork, Director of Bioinformatics and Biostatistics to STSI and Professor at the Scripps Research Institute. "These variations indicate genetic Predictor for patients who may be especially susceptible to eating disorders and diseases are more difficult to treat effectively.
Kaye said such genetic traits are also linked to people with higher and higher concerns over mistakes – characteristics associated with anorexia and bulimia.
Researchers from the Institute for collaborative study was responsible for the collection of data of the study, scientists at UCSD and STSI led the design of the study and analysis of results.
According to lead study author, cinnamon Bloss, PhD, Assistant Professor at the STSI, conclusions could ultimately help pave the way towards a more individualised approach in treating patients with eating disorders. "Anorexia and bulimia which possibly originate from many different causes, such as culture, family, life changes and personality traits," Bloss said. "But we know biology and genetics is important in terms of cause and can play a role in how different users respond to treatment. Understanding the genetics behind these treaties are important because ultimately that could help us customize treatment based on the genetic makeup of individuals, with the aim of more personalized and effective treatments. "
Anorexia and bulimia are serious and complex psychiatric disorders. Anorexia nervosa is characterized by an inability to maintain a normal body weight and a relentless pursuit of lachaniase, bulimia is characterized by recurrent episodes of binge eating. Recent studies, researchers, including Kaye speculate that anorexia and bulimia may share some risk factors, and that patients can be genetically predetermined to have personality traits and moods that make them susceptible to eating disorders.
"People with anorexia in particular are often resistant to treatment and lack of awareness of the medical consequences of their behavior, which can lead to chronic, prolonged illness and even death," said Kaye. "Became a problem for us, ' Prognostic factors Exist that could help clinicians to identify good versus poor results for treatments, including medications and psychotherapies? '"
The research team studied a total of 1,878 women in large-scale candidate gene Association study that was designed based on assumptions regarding the genes, pathways, and biological systems involved in sensitive to eating disorders. Most were people with lifetime diagnosis of either anorexia or anorexia and bulimia, hosted and lower body mass index, higher and higher concerns over mistakes from control issues.
Scientists identified then the top 25 most statistically significant SNPs (single nucleotide-other), after assessing a total of 5,151 SNPs in approximately 350 genes. According to Bloss, 10 of the 25 most strongly associated "haplotypes" (combinations of alleles for different genes are closely together on the same chromosome and who tend to be inherited together) involved in GABA genes, SNPs. An intronic SNP on chromosome 4 gene GABRGI showed the strongest correlation in chronic symptoms. "The study suggests that genes can be pre-dispose people in a cycle of chronic eating disorder," Bloss said, adding that additional studies are needed to confirm these compounds.
Provided by the University of California-San Diego (news: web)
US researchers found there was a small but positive impact from a law introduced in 2008 in New York that require chain restaurants with 20 or more branches at the national level, to provide calorie information on menus and menu boards of the city.
Rates of obesity in the United States at a high in both adults and children and is currently one-third of adults and 17% of children of all ages and adolescents are obese. Several studies support an association between fast food consumption and excessive energy intake, but customers often underestimate the number of calories on restaurant meals and before 2007, nutrition information was rarely available at the time of purchase.
Thus, a team of researchers decided to assess the impact of calorie labelling regulation on the energy content of the individual markets in fast food restaurants in New York. High street chains in England are going to launch a similar scheme, though optional, as part of the Deal the Government responsible for public health.
Investigations completed during lunch hours in spring 2007 (one year prior to the regulation) and in the spring of 2009 (nine months after implementation) randomly selected locations in 168 chains of fast food top 11 in the city.
Adult customers supplied in the registry collection and answers to the questions of the survey. Analyzed data from customers in a customers 2007 7,309 and 8,489 2009.
Overall, there has been no reduction in calories purchased across the full sample. However, the three big chains saw significant reductions.
For example, McDonalds, average energy per market decreased by 5.3% to Au Bon Pain, decreased by 14.4% and KFC, decreased by 6.4%. Together, these three chains represented 42% of all customers of the study.
However, the average energy content increased in the chain – Metro – by 17.8%, which was to a large extent, large parts.
The analysis also showed that 15% of clients reported using the calorie information and, on average, these customers purchased 106 fewer as by customers who do not see or use the information in calories.
Researchers say that calorie labelling is only part of a framework for addressing the epidemic of obesity and solicit additional strategies for reducing energy intake by the population. "We must focus particular attention on about training customers on how to interpret and use nutrition information" award.
In an accompanying editorial, Dr Susan Jebb from MRC human nutrition research center at Cambridge believes that labelling is one step forward, but must follow the changes in the food supply. She writes: "Calorie labeling will help consumers to make an informed choice about what they eat, but steady improvement in the diet of the nation will require a transformation of the food supply."
Provided by the British Medical Journal (news: web)
"This study represents a first step towards providing tools to describe objectively a chronic pain is a subjective experience. We found that when a patient is worsening the grief the usual, there are changes in the activity of the brain, "said Ajay Wasan, MD, MSc, lead author of the paper and a researcher at the management centre at BWH pain."These changes occur in the network of brain areas that process pain and mood. "
Researchers compared 16 patients suffering from chronic low back pain (CLBP) in 16 healthy subjects. Participants submitted three Imaging sessions. The first was a qualification and training session. During the second meeting, researchers used clinical maneuvers, such as pelvic inclination or raising straight leg, temporarily aggravate pain in the back. In the third session, the heat was applied to the skin in a matching volume levels of pain during the second session. Patients rated pain levels before and after the sessions and after boost during the sessions.
During the last two sessions, researchers used arterial spin emfainoysas technique, which allows to quantify the blood flow to particular areas of the brain over time. The amount of blood flow is an indicator of Neuron activity in the region of the brain. They found that there was an increase in activity in the brain of patients with CLBP, only when it faced a worsening of the chronic pain and not during the period of operation of heat or pain in healthy participants. Researchers also note that some of the areas of the brain that is activated when participants experienced a worsening of chronic pain has proved to be linked to other types of pain that found in other studies. However, researchers also observed a number of areas, including activation of upper posterior lobule, which are less often associated with pain in the previous investigation.
"While this study begins to reveal some of the basic physiology of the brain, such as processes pain, most studies are needed to help understand how the brain can change during the processing of pain and to examine the mechanisms of brain pain that improves, '' Wasan said. "We are approaching the description, on an objective level, how the body and the brain reacts when a patient reports having more pain. We are hopeful that this could lead to an understanding of the individual patient and neurocircuitry that knowledge may lead to therapies that are tailored to the individual. "
By Brigham and women's Hospital
The Institute for animal health has confirmed that it has received the HSE two communications earlier in the year.
The first notice in accordance with the IAH came to them when liquid material leaked some waste from the incineration plant in Pirbright Laboratory of the Institute kept. However, the staff was quick to respond to the incident. There were no traces of the virus have been verified in the liquid and all processes and procedures to avoid unwanted incident in the future. The same was the HSE informed.
A joint statement by IAH and biotechnology and biological of Sciences Research Council (BBSRC) said that the second notification because of cracking a container has been issued you virus contained foot and mouth disease. The jump came MBSC safety Cabinet note during the defrost cycle within a class II in a safe organic laboratory. The whole area was cleaned and leaked no germs in the outside world had no risk was involved.
Two notes were sent IAH to that. While the Institute has taken remedial action on one of them, the other that a complaint has been sent, confirmed speakers from HSE. He however comment on the contents of the notes.
The Pirbright site, where the IAH is, became the center of the outbreak of foot and mouth disease in August 2007. no charges have been framed then against it, because the exact cause of the outbreak could not be completed.
Basildon magistrates' Court instead of Castle point Borough Council guilty for violation of section 3 paragraph 1 of the health and safety at work, and so on. Be Canvey Iceland 1974, when a young girl at the age of 7 years met with an accident at the waterside swimming pool in the middle on May 2, 2009. You were fine £ 18,000 and costs of £ 7,500.
The HSE explored the matter said that with her great grandfather owned the Castle point Borough Council pool swim this young girl was gone. Suddenly, steckengeblieben their leave her hair in a vent of the water sampling outlet to the pool for almost 2 minutes and 36 seconds after air snatch. Her great-grandfather had take a cluster of her hair, to get them back to safety. She was on unconscious, blue and limp from the water, but slowly gained awareness brought.
The investigations revealed that the owner of the pool, who were also responsible for the security of its members it had failed to carry out their obligations with respect to the safety of the public with its pool. They had only a vent instead of two in the example outlet and therefore was not a back up for the fall that has blocked a vent. There were only two lifeguards in the service of those who fail at the see see the other the pool note the girl who caught because of the glare of the Sun, was while cleaning. The Court on hearing the HSE, the Council for the accident blamed.
A recent decision against concept Services Ltd provides the fact coverings and sheathing, that asbestos particles are not only very dangerous for the health and safety of the community, but also all companies, the violation of the asbestos be laws severely punished.
The case turned to a serious breach back concept covers and panels Services Ltd, which regard to accomplish the restore asbestos roof of 12 commercial units were asbestos two years in bath street in market Harborough between December 2008 and the end of January 2009. However, the case got at the highlighted and health controls specialists by Leicestershire County Council premises and asbestos found elements in Opera.
But everything, that this was done during the cleaning asbestos roof of concept roofing and cladding Services Ltd. tiled roof company to the water under full pressure when cleaning of asbestos tiles of the necessary legal method asbestos tiles carefully wash with water in a container. The complete Gush water next to the cleaning of asbestos tiles scattered also asbestos into the environment. With objections of traders due to the polluted environment, work ended abruptly when the heavy contamination came also to the attention of the company. Clean-Up of asbestos was then done by a qualified asbestos removal company monitoring the contamination to such a large scale and the presence of asbestos in the air, companies had to shut for many months with empty field close down their services and the car. Cleaning up asbestos took several months, during which the workers understood the extent of the situation, if contaminated their marks on the walls, asbestos was found in drains and bus stops.
Transaction of the whole thing, and the understanding of the seriousness of the case, Leicester magistrates' Court recently pursued and punished the company for violating the regulation 16 of the control of asbestos programme Regulations 2006. Although concept roofing and cladding Services Ltd accepts his mistake it was punished costs £ 12,000 in £ 22,375 as persecution.
According to the report cited in Leicester mercury said of concept covers and panels Stephen Climie Services Ltd, which up to 5 m was a subcontractor company and commissioned, cleaning asbestos roofs in the twelve business firms. However, even, before she had begun their work, almost four business areas already damaged were and drips and polluted area.
EU-OSHA (European Agency for safety and health) takes some of the initiatives for the prevention of road accidents, that work regularly faced with professional drivers. EU-OSHA has a Web site, to protect the drivers. The site offers the major reports on road accidents of the United Nations Decade of the action programme for road safety (2011-2020).
In 2009, a large number of truck drivers usually on light tasks due to road accidents their lives lost. Record says more than a thousand drivers been the victims of such accidental deaths this year. The victims were mainly vans and truck driver, motorcycle couriers, drivers, buses and coaches, drivers and other groups.
EU-OSHA will continue to say that the trucks and truck drivers are also expected to other hazards faced on the road, such as violence and robberies, dangers of vibration are common problems. You also glide and often fall from their vehicles and have serious injuries on her body. But EU-OSHA stresses the fact that it is the drivers about the dangers that they encounter on the road every day make quite a complicated task. It is to make even more difficult to comply with the General safety standards on road.
Majority of companies in this sector are small business houses and around 10 employees under each of these companies are busy. Much of the workers are also self-employed have an independent work style. .
The EU-OSHA Web sites provide useful practical examples of unwanted incidents on the road, especially in and around Europe. You have provided materials focusing on certain groups, such as drivers, driver of couriers, and similar categories taxi. The initiatives of the EU-OSHA to the road breakdowns include awareness-raising programmes for drivers, who work every day travel. These programs have significantly improved the health and safety of the driver.
Designers are designs of the hospital's accident and emergency (A & E) sections to formulate rethink in the effort, new methods for the cutting of hostility and physical assaults against NHS staff meanwhile said at least 69 million GBP each year affecting staff absences, additional safety and loss in productivity.
The 2009 NHS staff review of the care quality Commission revealed that something more than 10 people experienced violence physical of patients or patients families last year. Security management service NHS statistics also show that every day during 2009 / 10 on 150 violent attacks against medical staff, which more than 56,700 actual attacks in England as a whole was been reported compared.
'Reduction of violence and aggression in A & E design' is a project, which has been a year of operation is the Design Council operated and accredited by the Department of health.
The plan is to include health experts, patients, architects, designers and NHS operational staff in the preparation and the examination of the possible resolutions. A search launched across the UK by the Design Council for one or more teams that hospital are familiar with a and E patients and employees at these three NHS - Southampton University Hospitals NHS Trust, guys and St. Thomas's NHS Foundation Trust, and with Chesterfield Royal Hospital NHS Foundation Trust.
The results should include the following:
• Variations in interior design, including space use and redesign of the layout or start fresh goods and furniture.
• Review the clinical and non-clinical organization and service design.
• Better quality of information for patients and patient families.
The design team that WINS will produce an array of original solutions for visitors, staff and patients one better and safer experience a and E.
A case with incident, which scalded his judgment recently with Cambridge received Crown Court announce the company five workers in the NestlĂ© Purina food processing plant in Wisbech in 2006 guilty not adequate measures to protect of their workers in the exchange of a controlling system hydrostatic drive which is required according to law. The company, the also violations of section 2 paragraph 1 of the health and safety at work etc Act 1974 and 13 of regulation of pressure systems safety regulations adopted 2000 was ordered to pay £ 50,000 as fines in £ 26,634.15 as persecution charges.
The case is an incident centered round plant on the Wisbech occurred in the Nestlé Purina PetCare (UK) limited. On 4 August 2006 wore as part of their work, five employees of the company of maintenance of the HST. This processing food equipment work on high pressure steam powered powerful steam and boiling water from the equipment due to its not work correctly, causing severe burns care who worked on the hands, face and arms of five employees. All five employees were treated in the hospital for their burns with a in aesthetic plastic surgery on his arm due to the extent of causing the burning process.
HSE probe to the whole incident brought the company failure in light of not enough security measures to protect of their employees, as in the guidelines directed change and fixing systems control of high pressure processing equipment.
Justify the heavy penalty ordered the Court to Nestlé Purina PetCare (UK) limited, HSE Inspector noted that each organization responsibility to comply with the health and safety guidelines for the welfare of their employees. Therefore, must in the fix or change a controlling agreement such as regulators or switches in high pressure processing equipment follow correct procedures and instructions in order to protect their employees. If Nestlé Purina had implemented taking into account all processes with staff security would then this incident occurred not stated Brendan burns.
A research was to find out, performed via the stress level among the workers of the mental health charity. Spirit, called the research, found that most are workers fear, release from the Office, in the event that they mention about their mental health. Work is the most stress factor in their lives.
The study was carried out under the two thousand employees. It is believed by all five respondents that they are placed in the line of redundancy when they mention on stress. Around 22 percent of them lost their jobs as before had they their mental health issues to their employer announced.
Mr Paul farmer said the Chief Executive of the research, that stress and mental health unacceptable structure are concepts for modern work. Stress and pressure are inevitably aspects of our life, but not to understand, a mistake that will cost billions of pounds in companies is that there is a limit to anyone. The stigma of mental health problems is immense and the staff are fear silence about stress at work for fear of losing their jobs.
According to research, almost half of those surveyed workers are to take fear leaves for health issues. You can be considered redundant in such a case. The fear of redundancy seems to be more for public sector workers. One-third of workers be stressed if there is a reduction to the households. About two-thirds of the employees complain that they were put under immense pressure from the management level, especially after the downturn.
Four of all ten employees said, stress, or mental health is a taboo in the field of work and as excuses for other purposes. Stress is a reality of everyone's still unaddressed in the work tree today remain update problem life.